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Development and validation of a microbiological assay for determination of chlorhexidine digluconate in aqueous solution BJPS
Fiorentino,Flávia Angélica Másquio; Corrêa,Marcos Antonio; Salgado,Hérida Regina Nunes.
Chlorhexidine (CHX) is a broad-spectrum antiseptic that is used in many topical pharmaceutical formulations. Because there is no official microbiological assay reported in the literature that is used to quantify CHX, this paper reports the development and validation of a simple, sensitive, accurate and reproducible agar diffusion method for the dosage of chlorhexidine digluconate (CHX-D) in an aqueous solution. The assay is based on the inhibitory effect of CHX-D upon the strain of Staphylococcus aureus ATCC 25923, which is used as the test microorganism. The design 3x3 parallel-line model was used. The results were treated statistically by analysis of variance (ANOVA), and they were excellent in terms of linearity (r = 0.9999), presenting a significant...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Agar diffusion; Antiseptic; Chlorhexidine; Microbiological assay; Quality control; Validation.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200017
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Essai de traitement du sédiment contre le vibrio P1, lors d'un demi-élevage de palourdes dans la zone des Abers. ArchiMer
Barret, Jean.
Different treatments aiming to cure the grounds, which bad been contaminated by the vibrio P1 "brown-ring", have been carried out on some sites of on-growing, taking place in the Aber Benoit, in Brittany. The tested products were Lime, and an antiseptic "Agroseptil" which positive effects are admitted in pisciculture. The results (growth, survival and the presence of brown-ring), do not point out any difference between the various treatments. However, it looks as if the brownring has appeared latter than on other clam-fields located in the same area.This effect does not seem to be due to the various treatments of the soils, but to the antibiotic  bath of the clams bef ore seeding.
Tipo: Text Palavras-chave: Palourde; Tapes philippinarum; Vibrio P1; Sédiment; Anneaux brun; Traitement; Antiseptique; Agroseptil; Chaux; Manila clam; Tapes philippinarum; Vibrio P1; Soil; Brown-ring; Treatments; Antiseptic; Agroseptil; Line.
Ano: 1992 URL: http://archimer.ifremer.fr/doc/00425/53673/54513.pdf
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Recherche et dosage de quelques antiseptiques dans les semi-conserves de poisson. ArchiMer
Fougeras Lavergnolle, Jean.
Tipo: Text Palavras-chave: Risk; Antiseptic; Preserve; Proportion; Research; Risques; Antiseptiques; Conservation; Dosage; Recherche.
Ano: 1972 URL: http://archimer.ifremer.fr/doc/1972/publication-2070.pdf
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Toxicological effects of ciprofloxacin and chlorhexidine on growth and chlorophyll a synthesis of freshwater cyanobacteria BJPS
Azevedo,Fernanda Cristina Rezende; Vaz,Izabela Cristina Dias; Barbosa,Francisco Antônio Rodrigues; Magalhães,Sérgia Maria Starling.
Cyanobacteria are phytoplanktonic microorganisms that are susceptible to the deleterious effects of pharmaceutical residues in the aquatic environment, which poses a challenge to the environment exposed to diverse pharmaceutical products and their potential effects. The objective of this study was to evaluate the effects of the antibiotic substances ciprofloxacin and chlorhexidine in pharmaceutical preparations on the growth and production of chlorophyll of two cyanobacterial strains, Microcystis aeruginosa and Microcystis panniformis, isolated from a lake in a Brazilian environmental protection area. The EC50 and EC10 of chlorhexidine for M. aeruginosa were 206.4 µg/L and 108.5 µg/L, respectively, and for M. panniformis were 171.4 µg/L and 116.6 µg/L,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ecotoxicological test; Antibiotics; Antiseptic; Contaminants of emerging interest; Growth inhibition.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100588
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